Analyzing how coronaviruses interact with hosts and adapt
Project 2 - Ex Vivo Analysis of Coronavirus Tropism, Adaptation, Replication, and Host Response
['FUNDING_OTHER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11005782
This study is looking at how coronaviruses, like the one that causes COVID-19, interact with human and bat cells to learn how they adapt and spread, with the hope of finding new ways to treat COVID-19 and similar infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11005782 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between coronaviruses, such as SARS-CoV-2, and their hosts to understand how these viruses adapt and replicate. By using advanced techniques like proteomics, transcriptomics, and epigenomics, researchers will analyze virus-host interactions in human and bat cells. The goal is to identify key proteins and pathways that influence disease severity and could lead to the development of new antiviral therapies. Patients may benefit from insights gained that could improve treatment options for COVID-19 and related infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been infected with SARS-CoV-2 or are at risk of severe COVID-19 outcomes.
Not a fit: Patients who have not been infected with coronaviruses or those with unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral therapies for COVID-19 and other coronavirus infections.
How similar studies have performed: Other research has shown success in understanding virus-host interactions, making this approach promising for developing new treatments.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARCIA-SASTRE, ADOLFO — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: GARCIA-SASTRE, ADOLFO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: after COVID-19 infection, after infection by SARS-CoV-2, after SARS-CoV-2 infection, after SARS-CoV2 infection, after severe acute respiratory distress syndrome CoV-2 infection