Analyzing how chromatin features interact in cancer cells
Official title: Proximity epigenomics for context-specific analysis of complex chromatin features
Funded at Johns Hopkins University · NIH-11051182 · Data updated 2026-11-12
This study is looking at how certain features in cancer cells interact with each other to help us understand cancer better, which could lead to new and better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 6, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $229,659 |
| NIH project number | 5R61CA278503-02 |
| Project ID | NIH-11051182 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with various types of cancer who are interested in understanding the genetic and molecular basis of their disease.
✕Less likely to help
Patients with non-cancerous conditions or those not interested in genetic research may not receive any benefit from this research.
What this research studies
This research focuses on understanding the complex interactions of chromatin features in cancer cells, which are crucial for gene regulation and genome maintenance. By developing a new technique for genome-scale analysis, the researchers aim to improve the mapping of chromatin interactions that are often overlooked in traditional methods. This approach will allow for a better understanding of how these interactions contribute to cancer progression and may lead to more effective treatments. Patients may benefit from insights gained about the molecular mechanisms of their cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer at the molecular level.
How similar studies have gone: Previous research has shown promise in using advanced chromatin mapping techniques, indicating that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Oberdoerffer, Philipp — Johns Hopkins University
- Study coordinator: Oberdoerffer, Philipp
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.