Analyzing how antibodies interact with immune cells to enhance their functions
Systematic, molecular level analysis of the Fc receptor ligation on antibody effector functions
This study is looking at how antibodies help our immune system fight off infections by activating immune cells, and it's designed for anyone interested in understanding how our body defends itself against germs.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-10744720 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which antibodies trigger immune responses, specifically focusing on how they activate immune cells to eliminate pathogens. By examining the interactions between antibodies and Fc receptors on immune cells, the study aims to understand the processes of antibody-dependent cell phagocytosis (ADCP) and antibody-dependent cell cytotoxicity (ADCC). The researchers will utilize advanced techniques, including bulk assays and single-cell analysis, to quantify these immune responses and identify the factors that influence their effectiveness.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing treatment with therapeutic antibodies for infections or cancers.
Not a fit: Patients who are not receiving antibody-based therapies or those with conditions unrelated to immune response may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for infections and cancers by enhancing the efficacy of antibody treatments.
How similar studies have performed: Previous research has shown promising results in understanding antibody interactions with immune cells, indicating that this approach has potential for significant advancements.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Georgiou, George Georgiou — University of Texas at Austin
- Study coordinator: Georgiou, George Georgiou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.