Analyzing how aging affects individual cells using advanced imaging techniques
Official title: Single-Cell Molecular Pathway Analysis in Aging Systems via Novel Mass Cytometry Methods
Funded at University of Minnesota · NIH-11098564 · Data updated 2026-11-12
This study is looking at how different types of cells change as they get older, using special techniques to see how they react to treatments and what happens to them over time, which could help us find new ways to treat age-related diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | June 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $384,294 |
| NIH project number | 5R01AG084804-02 |
| Project ID | NIH-11098564 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related health issues or conditions that affect cellular function.
✕Less likely to help
Patients with acute, non-age-related conditions or those not experiencing any age-associated effects may not benefit from this research.
What this research studies
This research focuses on understanding the unique characteristics of different cell types as they age, using innovative methods to analyze individual cells rather than bulk samples. By employing advanced mass cytometry techniques, the study aims to monitor metabolic processes in live cells, such as how they respond to treatments and how their functions change over time. The research will specifically investigate the relationship between cellular aging and processes like autophagy and senescence in mouse models, providing insights that could lead to new therapeutic strategies for age-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating age-related conditions by providing targeted therapies based on individual cellular responses.
How similar studies have gone: Previous research has shown promise in using single-cell analysis techniques to understand cellular aging, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Arriaga, Edgar a — University of Minnesota
- Study coordinator: Arriaga, Edgar a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.