Analyzing heart function and quality of life in patients with heart failure.
Official title: Retrospective Single Image Multi-endPoint anaLysis (SIMPL) to define pathophysiologic mechanisms of heart failure with preserved ejection fraction.
Funded at University of Texas Arlington · NIH-10913966 · Data updated 2026-11-12
This study is looking at heart failure with preserved ejection fraction (HFpEF) to better understand how it affects your ability to exercise and feel good, using special heart images to compare patients with HFpEF to healthy people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $122,220 |
| NIH project number | 5R21HL167171-02 |
| Project ID | NIH-10913966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with heart failure with preserved ejection fraction (HFpEF) and age- and sex-matched healthy controls.
✕Less likely to help
Patients with heart failure with reduced ejection fraction or those without heart failure may not benefit from this research.
What this research studies
This research investigates heart failure with preserved ejection fraction (HFpEF), a common and serious condition that significantly affects patients' quality of life. By utilizing existing cardiac magnetic resonance images from a database, the study aims to identify the underlying mechanisms of HFpEF and how they relate to exercise tolerance and overall well-being. The innovative Single Image Multi-endPoint analysis (SIMPL) will compare heart function and other factors between patients with HFpEF and healthy individuals. This approach seeks to enhance our understanding of HFpEF and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies and improved quality of life for patients suffering from heart failure.
How similar studies have gone: Previous research has shown promise in using similar imaging techniques to analyze heart function, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: Nelson, Michael Douglas — University of Texas Arlington
- Study coordinator: Nelson, Michael Douglas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.