Analyzing heart conditions caused by fat tissue infiltration
Official title: Heart Digital Twin Analysis of Arrhythmias due to Infiltrating Adiposity
Funded at Johns Hopkins University · NIH-11159624 · Data updated 2026-11-12
This study is looking at how fat tissue in the heart can influence the risk of irregular heartbeats in people who have had heart attacks, and it aims to use advanced technology to create a digital model of the heart that helps doctors improve treatment for these heart issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $643,770 |
| NIH project number | 5R01HL174440-02 |
| Project ID | NIH-11159624 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with ischemic cardiomyopathy who have experienced a myocardial infarction and are at risk for ventricular arrhythmias.
✕Less likely to help
Patients without a history of heart disease or those who do not have ischemic cardiomyopathy may not benefit from this research.
What this research studies
This research investigates how infiltrating adipose tissue affects the risk of ventricular arrhythmias in patients with a history of heart attacks. By using advanced techniques such as personalized computational modeling, imaging, and artificial intelligence, the study aims to create a digital twin of the heart to better understand the relationship between fat tissue and scar formation. This approach seeks to improve the effectiveness of treatments for arrhythmias by providing more precise guidance for ablation procedures.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from life-threatening heart arrhythmias.
How similar studies have gone: While the specific approach of using a digital twin for this purpose is novel, previous research has shown promise in understanding arrhythmias through advanced imaging and modeling techniques.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Trayanova, Natalia a. — Johns Hopkins University
- Study coordinator: Trayanova, Natalia a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.