Analyzing genetic changes in human tissues over time
Official title: Computational genomic analysis of genomic variations in human tissues
Funded at Rutgers Biomedical and Health Sciences · NIH-10933392 · Data updated 2026-11-12
This study is looking at how our genes change over time in different parts of our bodies because of aging and things around us, and it aims to help people understand how these changes might affect their health, especially for conditions like cancer and autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | September 25, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $392,500 |
| NIH project number | 5R35GM149224-02 |
| Project ID | NIH-10933392 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with a history of genetic disorders, autoimmune diseases, or those at risk for cancers.
✕Less likely to help
Patients with stable, non-genetic conditions or those not affected by the diseases being studied may not receive direct benefits.
What this research studies
This research investigates how genetic variations accumulate in human tissues due to factors like aging and environmental exposures. By utilizing advanced genomic technologies, the study aims to understand the patterns of somatic mutations that occur in both healthy and diseased tissues. The approach involves detailed computational analysis to characterize these mutations and their potential implications for various health conditions, including cancer and autoimmune diseases. Patients may benefit from insights into how these genetic changes affect their health and disease progression.
Why it matters
Potential benefit: If successful, this research could lead to improved early diagnosis and personalized treatment strategies for various diseases.
How similar studies have gone: Other research has shown success in understanding genetic variations in tissues, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: De, Subhajyoti — Rutgers Biomedical and Health Sciences
- Study coordinator: De, Subhajyoti
Related research
Other NIH-funded projects on the same topics.
-
Methylation and metabolism signals linked to lung function in kids with asthma
This grant looks at how genes, environment, and small chemical changes in the body together affect how lung function changes over time in children with asthma.
-
FEND-TB: Faster, better TB tests for all ages
A multi-institutional project aims to develop and validate faster TB diagnostic tools and drug-susceptibility tests so people of all ages, including children and those with extrapulmonary TB, can get quicker and more accurate results.
-
FEND-TB: Accelerating TB Diagnostics and Drug Susceptibility Testing
A multi‑institution collaboration will test new TB diagnostic tools and rapid drug-susceptibility tests to improve detection and treatment for people of all ages, including children and those with hard-to-diagnose TB.
-
Game-based mobile app to help pregnant women with overweight/obesity manage weight in Nepal
A new app designed for pregnant women in Nepal with overweight or obesity to help manage weight gain during pregnancy and reduce weight retention after birth.
-
Environmental factors and Lewy body dementia: linking claims data with lab work
Aims to find environmental factors that influence Lewy body dementia by combining big health data with lab studies, to understand what might worsen the condition and who is most at risk.
-
Identifying how ableism affects pregnancy and postpartum care for women with intellectual and developmental disabilities on Medicaid
This grant studies how bias and barriers in the healthcare system affect pregnancy and postpartum outcomes for women with intellectual and developmental disabilities who are on Medicaid and their babies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.