Analyzing genetic changes in cancer to improve diagnostics
Center for the Comprehensive Analysis of Cancer Somatic Copy-Number Alterations, Rearrangements, and Long-Read Sequencing Data
This study is looking at how changes in the DNA of cancer cells can affect their growth and response to treatment, using advanced technology to better understand these changes in patients' tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10911807 on NIH RePORTER |
What this research studies
This research focuses on analyzing structural variants in cancer, particularly somatic copy-number alterations and rearrangements. By utilizing advanced sequencing techniques, including long-read data, the project aims to enhance our understanding of cancer genomics. Patients' tumor genomes will be reconstructed to evaluate their evolutionary history and genetic diversity, which can provide insights into tumor behavior and treatment responses. The research will also explore the mechanisms of DNA damage and repair in cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with various types of cancer who are undergoing genomic analysis.
Not a fit: Patients with non-cancerous conditions or those not undergoing genomic testing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate cancer diagnostics and personalized treatment strategies.
How similar studies have performed: Previous research in cancer genomics has shown promising results in understanding structural variants and their implications for treatment.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Beroukhim, Rameen — Broad Institute, INC.
- Study coordinator: Beroukhim, Rameen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.