Analyzing genetic and epigenetic factors in serious mental illness
Official title: Large-scale transcriptome and epigenome association analysis across multiple traits
Funded at James J Peters VA Medical Center · NIH-11109531 · Data updated 2026-11-12
This study is looking at how our genes might affect serious mental health issues by using information from over 650,000 veterans, and it hopes to find ways to create more personalized treatments that could help people manage their mental health better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | October 1, 2018 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX004189-07 |
| Project ID | NIH-11109531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include veterans with a history of serious mental illness or those interested in understanding their genetic predisposition to such conditions.
✕Less likely to help
Patients without a history of serious mental illness or those not participating in the Million Veteran Program may not receive direct benefits from this research.
What this research studies
This research investigates how genetic and epigenetic factors contribute to serious mental illnesses by utilizing data from the Million Veteran Program, which includes genetic information from over 650,000 veterans. The study aims to identify specific genetic variants that influence disease risk and understand their functional relevance. By focusing on regulatory variants that affect gene expression, the research seeks to enhance personalized treatment approaches in psychiatry. Patients may benefit from insights that could lead to more tailored prevention and treatment strategies for mental health conditions.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for individuals with serious mental illnesses.
How similar studies have gone: Previous research utilizing large biobanks and genetic data has shown promise in identifying risk factors for mental illnesses, suggesting that this approach could yield significant insights.
Where this research is happening
-
James J Peters VA Medical Center
Bronx, United States Active
Researchers
- Principal investigator: Roussos, Panagiotis — James J Peters VA Medical Center
- Study coordinator: Roussos, Panagiotis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.