Analyzing genes and chromatin in the brain related to addiction
Gene and Chromatin Analysis Core
This study is looking at how addiction to drugs like cocaine affects the genes and structure of brain cells, and it’s for anyone interested in understanding more about the biology behind addiction to help find better treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11158915 on NIH RePORTER |
What this research studies
This research focuses on understanding how genes and chromatin structure in the brain are affected by addiction, particularly to psychostimulants. It utilizes advanced sequencing techniques to analyze gene expression and chromatin accessibility in both animal models and human brain tissue. By examining specific cell types within brain reward regions, the research aims to uncover the biological mechanisms underlying addictive disorders. The findings could lead to improved strategies for treating substance use disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with substance use disorders, particularly those addicted to psychostimulants.
Not a fit: Patients who do not have substance use disorders or those not affected by psychostimulant addiction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights into the biological basis of addiction, potentially leading to more effective treatments for patients with substance use disorders.
How similar studies have performed: Other research has shown success in using advanced genomic techniques to study addiction, indicating that this approach is promising and builds on established methodologies.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Shen, Li — Icahn School of Medicine at Mount Sinai
- Study coordinator: Shen, Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.