Analyzing gene regulation at the single-cell level
Official title: High-throughput Single Cell Co-assay of Histone Modifications andTranscriptome
Funded at Epigenome Technologies, INC. · NIH-10880624 · Data updated 2026-11-12
This study is looking at how genes are controlled in different cells, especially in cancer, to help us understand what makes each cell unique, using new methods that make the testing easier and more affordable.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Epigenome Technologies, INC. NIH-funded |
| Lab location | 1 site (San Diego, UNITED STATES) |
| Project start | July 3, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $825,111 |
| NIH project number | 5R44GM146330-03 |
| Project ID | NIH-10880624 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heritable diseases, developmental disorders, or cancer who are willing to provide tissue samples for analysis.
✕Less likely to help
Patients with conditions unrelated to gene regulation or those who cannot provide tissue samples may not benefit from this research.
What this research studies
This research focuses on understanding how gene regulation varies among individual cells, particularly in the context of diseases like cancer. By using advanced techniques that analyze both histone modifications and RNA expression in single cells, the study aims to uncover the unique gene regulatory programs that exist within different cell types. The approach involves developing automated protocols and laboratory systems to enhance the efficiency and cost-effectiveness of these analyses, ultimately providing deeper insights into cellular behavior in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to more precise and personalized treatments for diseases by identifying specific gene regulatory mechanisms at the single-cell level.
How similar studies have gone: Previous research using single-cell technologies has shown promise in understanding cellular heterogeneity, indicating that this approach could yield valuable insights.
Where this research is happening
-
Epigenome Technologies, INC.
San Diego, United States Active
Researchers
- Principal investigator: Hartl, Christopher — Epigenome Technologies, INC.
- Study coordinator: Hartl, Christopher
Related research
Other NIH-funded projects on the same topics.
-
Cell-by-cell maps of gene regulation in Alzheimer's brains
Creating detailed, cell-level maps of how genes and their on/off switches work in Alzheimer's and healthy brains to help researchers develop better tests and treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.