Analyzing gene and chromatin data in the brain
Gene and Chromatin Analysis Core
This study is looking at how genes and their structures in the brain affect behavior, especially in people with substance use disorders, by using advanced techniques to analyze brain tissue from both humans and rodents, and it aims to create better tools for understanding this complex information.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10934809 on NIH RePORTER |
What this research studies
This research focuses on analyzing complex gene expression and chromatin data from brain tissues, particularly in relation to substance use disorders. It employs advanced sequencing techniques such as RNA sequencing and ATAC sequencing to study specific cell types in the brain. The project aims to improve the understanding of how genes and chromatin structure influence brain function and behavior, using both rodent models and human samples. By developing better bioinformatics tools, the research seeks to enhance the analysis of these intricate datasets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with substance use disorders, particularly those willing to provide brain tissue samples for analysis.
Not a fit: Patients without substance use disorders or those not willing to participate in tissue sampling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic and chromatin factors contributing to substance use disorders, potentially informing more effective treatments.
How similar studies have performed: Other research has successfully utilized similar genomic and chromatin analysis techniques to advance understanding of brain disorders, indicating a promising approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Shen, Li — Icahn School of Medicine at Mount Sinai
- Study coordinator: Shen, Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.