Analyzing gene activity in individual cells
Gene set analysis of single cell genomics
This study is looking at how individual cells in tissue samples behave and interact by examining their genes and proteins, which could help us better understand diseases like cancer and improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10899480 on NIH RePORTER |
What this research studies
This research focuses on using advanced single cell assays to measure various genetic and protein expressions in individual cells from tissue samples. By employing bioinformatics methods, the study aims to improve the understanding of how individual cells behave and interact within their environment, rather than relying on average data from groups of cells. This approach could lead to more precise insights into cellular functions and the underlying mechanisms of diseases, particularly cancers. The research will utilize gene set testing to analyze pathways that reflect the state of individual cells, enhancing the accuracy of cellular characterization.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with various types of cancers or other conditions that involve complex tissue interactions.
Not a fit: Patients with conditions that do not involve significant cellular heterogeneity or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for cancer and other diseases by providing a clearer understanding of individual cell behavior.
How similar studies have performed: Previous research has shown promising results using similar single cell analysis techniques, indicating that this approach has the potential for significant advancements in understanding cellular dynamics.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Frost, Hildreth — Dartmouth College
- Study coordinator: Frost, Hildreth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.