Analyzing gene activity and networks in inflammation
Official title: Transcriptome & Networks Analysis Core
Funded at South Dakota State University · NIH-11035161 · Data updated 2026-11-12
This study is looking at how our genes behave during inflammation to help find better treatments for people with inflammatory conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | South Dakota State University NIH-funded |
| Lab location | 1 site (Brookings, United States) |
| Project start | March 20, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $353,285 |
| NIH project number | 5P20GM135008-04 |
| Project ID | NIH-11035161 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals with inflammatory conditions or those interested in the genetic basis of such diseases.
✕Less likely to help
Patients with non-inflammatory conditions or those not affected by gene expression changes related to inflammation may not receive benefits from this research.
What this research studies
This research focuses on understanding how genes are expressed and interact during inflammation using advanced technologies like RNA sequencing and CRISPR screening. By analyzing large datasets, the project aims to uncover the molecular pathways involved in inflammatory responses. Patients may benefit from insights gained through this research, which could lead to improved treatments for inflammatory conditions. The research team includes experts in genomics and bioinformatics who will facilitate the analysis and interpretation of complex biological data.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating inflammatory diseases by identifying key molecular pathways.
How similar studies have gone: Previous research using similar high-throughput omics technologies has shown promising results in understanding complex biological processes, indicating that this approach is both viable and potentially impactful.
Where this research is happening
-
South Dakota State University
Brookings, United States Active
Researchers
- Principal investigator: Gonzalez Hernandez, Jose Luis — South Dakota State University
- Study coordinator: Gonzalez Hernandez, Jose Luis
Related research
Other NIH-funded projects on the same topics.
-
Identifying protective mechanisms to lower artery cholesterol
A study to find ways to boost cholesterol removal from artery walls to prevent heart attacks and strokes.
-
Growth and survival of Listeria in pet foods
This grant studies how the bacteria Listeria monocytogenes grows and survives in different types of pet foods to understand risks to pets and people.
-
Antibiotic resistance monitoring of meat and seafood sold in South Dakota and North Dakota
This project tests how common antibiotic-resistant bacteria are in store-bought meat and seafood from SD and ND to help protect public health.
-
WGS-based pathogen profiling to combat antimicrobial resistance in veterinary settings
This grant supports using whole genome sequencing at a veterinary lab to help track and reduce antimicrobial resistance in bacteria from animals.
-
Interactive, reproducible enrichment-analysis tool for cancer-related genes
A user-friendly, web-based tool helps researchers understand how gene changes relate to cancer biology in a clear, interactive way.
-
How tiny cellular antennae (primary cilia) control lymphatic vessel growth
Researchers are looking at how tiny cellular antennae called primary cilia control lymphatic vessel growth to help people with lymphedema, transplant complications, or cancer-related swelling.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.