Analyzing epigenetic changes in single kidney cells
Official title: in situ Epigenetic Profiling of Single Cells in Kidney
Funded at University of Washington · NIH-10932504 · Data updated 2026-11-12
This study is creating new tools to look closely at how aging changes kidney cells, helping us understand their structure and function better, which could be useful for anyone interested in kidney health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $86,433 |
| NIH project number | 3R21DK136026-02S1 |
| Project ID | NIH-10932504 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may be experiencing kidney-related health issues.
✕Less likely to help
Patients under 21 years old or those without kidney conditions may not benefit from this research.
What this research studies
This research aims to develop innovative tools to analyze the epigenetic state and chromatin organization in individual kidney cells. By adapting a technology called SCEPTRE, the researchers will be able to directly measure specific histone modifications in kidney tissues. Additionally, a new method called APT-FISH will be employed to profile changes in chromatin structure. These tools will be used alongside advanced imaging techniques to explore how aging affects kidney cells at a molecular level.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of age-related kidney diseases.
How similar studies have gone: Other research has shown promise in using similar epigenetic profiling techniques, indicating potential for success in this area.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Vaughan, Joshua — University of Washington
- Study coordinator: Vaughan, Joshua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.