Analyzing epigenetic changes in single kidney cells
in situ Epigenetic Profiling of Single Cells in Kidney
['FUNDING_R21'] · UNIVERSITY OF WASHINGTON · NIH-10932504
This study is creating new tools to look closely at how aging changes kidney cells, helping us understand their structure and function better, which could be useful for anyone interested in kidney health.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10932504 on ClinicalTrials.gov |
What this research studies
This research aims to develop innovative tools to analyze the epigenetic state and chromatin organization in individual kidney cells. By adapting a technology called SCEPTRE, the researchers will be able to directly measure specific histone modifications in kidney tissues. Additionally, a new method called APT-FISH will be employed to profile changes in chromatin structure. These tools will be used alongside advanced imaging techniques to explore how aging affects kidney cells at a molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing kidney-related health issues.
Not a fit: Patients under 21 years old or those without kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of age-related kidney diseases.
How similar studies have performed: Other research has shown promise in using similar epigenetic profiling techniques, indicating potential for success in this area.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAUGHAN, JOSHUA — UNIVERSITY OF WASHINGTON
- Study coordinator: VAUGHAN, JOSHUA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.