Analyzing epigenetic changes in single kidney cells
in situ Epigenetic Profiling of Single Cells in Kidney
['FUNDING_R21'] · UNIVERSITY OF WASHINGTON · NIH-10802382
This study is exploring new ways to look at how tiny changes in kidney cells can affect their health as we age, which could help patients understand more about how aging impacts kidney function.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10802382 on ClinicalTrials.gov |
What this research studies
This research aims to develop innovative tools to analyze the epigenetic state and chromatin organization in individual kidney cells. It utilizes a technology called SCEPTRE to quantify histone modifications directly in kidney tissues, alongside a new method called APT-FISH to profile changes in chromatin structure. By employing advanced imaging techniques, the study seeks to connect nanoscale kidney physiology with epigenetic changes, particularly in the context of aging and kidney health. Patients may benefit from insights into how aging affects kidney function at a cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults aged 65 and above who may be experiencing chronic kidney conditions.
Not a fit: Patients under 21 years old or those without kidney-related health issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of kidney aging and potential new strategies for treating age-related kidney diseases.
How similar studies have performed: Previous research has shown promise in using similar epigenetic profiling techniques in other tissues, suggesting potential for success in kidney studies.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAUGHAN, JOSHUA — UNIVERSITY OF WASHINGTON
- Study coordinator: VAUGHAN, JOSHUA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.