Analyzing DNA in urine to track urinary infections after kidney transplants
Metagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantation
['FUNDING_R01'] · CORNELL UNIVERSITY · NIH-10796842
This study is looking at a new way to better diagnose and track urinary tract infections in people who have had a kidney transplant, using advanced techniques to find infections more accurately and help doctors choose the right treatment faster.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CORNELL UNIVERSITY (nih funded) |
| Locations | 1 site (ITHACA, UNITED STATES) |
| Trial ID | NIH-10796842 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the diagnosis and monitoring of urinary tract infections (UTIs) in patients who have undergone kidney transplantation. By utilizing advanced techniques such as metagenomic sequencing of cell-free DNA found in urine, the study aims to identify infections more accurately than traditional bacterial cultures. This approach not only detects the presence of bacteria but also provides insights into antibiotic resistance and the body's response to infections. The goal is to enhance patient outcomes by enabling timely and precise interventions for UTIs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently undergone kidney transplantation and are at risk for urinary tract infections.
Not a fit: Patients who have not had a kidney transplant or those who do not experience urinary tract infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management of urinary infections in kidney transplant recipients, potentially reducing complications and improving transplant success rates.
How similar studies have performed: Other research has shown promise in using metagenomic approaches for diagnosing infections, indicating that this methodology could be effective in this context as well.
Where this research is happening
ITHACA, UNITED STATES
- CORNELL UNIVERSITY — ITHACA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DE VLAMINCK, IWIJN — CORNELL UNIVERSITY
- Study coordinator: DE VLAMINCK, IWIJN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Infectious Disease Pathway, Infectious Diseases, Infectious Disorder, Communicable Diseases