Analyzing DNA in stool and blood to detect necrotizing enterocolitis in premature infants
Non-invasive analysis of methylated cell free DNA in necrotizing enterocolitis
This study is looking for a gentle way to spot early signs of necrotizing enterocolitis (NEC) in premature babies by checking for special DNA markers in their stool and blood, which could help doctors catch the condition early and provide better care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10843909 on NIH RePORTER |
What this research studies
This research focuses on necrotizing enterocolitis (NEC), a serious condition affecting premature infants. The team aims to develop a non-invasive method to detect early signs of NEC by analyzing methylated cell-free DNA found in stool and blood samples. By studying genetic and environmental factors, the researchers hope to identify specific DNA methylation patterns that can serve as biomarkers for early detection. This approach could lead to timely interventions that may prevent the severe complications associated with NEC.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants who are at risk for developing necrotizing enterocolitis.
Not a fit: Patients who are not premature or those who have already been diagnosed with necrotizing enterocolitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early detection of necrotizing enterocolitis, significantly reducing morbidity and mortality in premature infants.
How similar studies have performed: Other research has shown promise in using DNA methylation patterns for disease detection, suggesting that this approach may be viable.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Good, Misty L — Univ of North Carolina Chapel Hill
- Study coordinator: Good, Misty L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.