Analyzing DNA from urine exosomes to improve bladder cancer detection
Rigorous and reproducible mutational analysis of the urinary exosomal DNA
['FUNDING_R01'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-10669649
This study is looking at DNA from tiny particles in urine to find genetic changes linked to bladder cancer, with the goal of helping doctors choose the best treatments for patients based on their unique tumor characteristics.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10669649 on ClinicalTrials.gov |
What this research studies
This research focuses on analyzing DNA found in exosomes released from urine to identify genetic mutations associated with bladder cancer. By optimizing methods for collecting and analyzing this DNA, the study aims to create a reliable process for detecting actionable therapy targets and biomarkers. The approach involves using advanced sequencing techniques to uncover mutations that could inform treatment decisions for patients with bladder cancer. This could lead to more personalized and effective treatment options based on the genetic profile of the tumor.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with bladder cancer who are undergoing treatment or monitoring.
Not a fit: Patients without bladder cancer or those who do not have access to urine sample collection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved detection and treatment options for bladder cancer patients.
How similar studies have performed: Previous studies have shown promise in using exosomal DNA for cancer detection, but this research aims to establish a more rigorous and reproducible methodology.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KALLURI, RAGHU — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: KALLURI, RAGHU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bladder Cancer, Urinary Bladder Cancer, Cancers, neoplasm/cancer