Analyzing DNA changes in oral cells of smokers and head and neck cancer patients
High resolution mass spectrometric profile analysis of carcinogen-DNA adducts in oral cells of cigarette smokers and squamous cell carcinoma of the head and neck
This study is looking at how smoking and head and neck cancer might be linked by checking for harmful DNA changes in the mouth cells of smokers and cancer patients, and we’d love to have patients help by providing samples to learn more about what causes cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10914067 on NIH RePORTER |
What this research studies
This research investigates the presence of harmful DNA changes, known as DNA adducts, in the oral cells of individuals who smoke cigarettes and those diagnosed with squamous cell carcinoma of the head and neck. Using advanced techniques like liquid chromatography and mass spectrometry, the study aims to identify and quantify specific DNA adducts that may contribute to cancer development. By comparing samples from smokers and non-smokers, the research seeks to understand how these DNA changes correlate with cancer risk. Patients may be involved in providing oral cell samples to help advance our understanding of cancer causes.
Who could benefit from this research
Good fit: Ideal candidates for participation include adults aged 21 and older who are current or former cigarette smokers.
Not a fit: Patients who do not smoke or consume alcohol and do not have a history of head and neck cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and early detection methods for head and neck cancer.
How similar studies have performed: Previous research has shown promising results in analyzing DNA adducts related to cancer, indicating that this approach could yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Hecht, Stephen S — University of Minnesota
- Study coordinator: Hecht, Stephen S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.