Analyzing DNA and RNA modifications to understand health and disease
Official title: Aquisition of a Orbitrap IQ-X Mass Spectrometer System with Vanquish Flex UHPLC System for Nucleic Acid Adductomics
Funded at University of South Florida · NIH-10852507 · Data updated 2026-11-12
This study is all about using a special machine to look closely at changes in DNA and RNA that can help us understand diseases like cancer, and it's designed for researchers at the University of South Florida who are working on important health projects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 15, 2024 |
| Project end | August 14, 2025 |
| Funding year | 2024 |
| Award (this year) | $949,116 |
| NIH project number | 1S10OD036306-01 |
| Project ID | NIH-10852507 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to genomic instability, such as cancer or other genetic disorders.
✕Less likely to help
Patients with no known genetic modifications or those not affected by diseases related to nucleic acid adducts may not benefit from this research.
What this research studies
This research focuses on acquiring advanced mass spectrometry equipment to analyze nucleic acid modifications in detail. By using the Orbitrap IQ-X Mass Spectrometer, researchers aim to identify various types of modifications in DNA and RNA, which are crucial for understanding their roles in diseases such as cancer. The project will enable high-resolution analysis of low-level small molecules in complex biological samples, providing insights into how these modifications contribute to health and disease. This unique capability will support multiple NIH-funded projects at the University of South Florida.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic modifications that influence disease, potentially improving diagnosis and treatment options for patients.
How similar studies have gone: Other research has shown success in using advanced mass spectrometry techniques for analyzing nucleic acids, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Cooke, Marcus Stanley — University of South Florida
- Study coordinator: Cooke, Marcus Stanley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.