Analyzing cell-free DNA to improve diagnosis and treatment for brain lymphomas
Cell-free DNA-Based Analysis for Diagnosis, Monitoring and Optimization of Therapy for Patients with Primary Central Nervous System Lymphomas
['FUNDING_R21'] · JOHNS HOPKINS UNIVERSITY · NIH-10705063
This study is looking at a new way to help people with primary central nervous system lymphoma (PCNSL) by using a simple blood test to check for cancer markers, which could make it easier to diagnose and track the disease without needing risky surgeries.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10705063 on ClinicalTrials.gov |
What this research studies
This research focuses on primary central nervous system lymphoma (PCNSL), a rare and aggressive type of cancer affecting the brain. It aims to develop a non-invasive method using cell-free DNA analysis to diagnose and monitor the disease, potentially reducing the need for risky surgical biopsies. By identifying biomarkers in the blood, the research seeks to optimize therapy and improve patient outcomes, especially for those who do not respond to standard treatments. The study will involve patients diagnosed with PCNSL to evaluate the effectiveness of this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with primary central nervous system lymphoma, particularly those who may not tolerate standard treatments.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with primary central nervous system lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective diagnostic and treatment options for patients with primary central nervous system lymphoma.
How similar studies have performed: Other research has shown promise in using cell-free DNA for cancer diagnostics, indicating that this approach could be a significant advancement in the field.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BETTEGOWDA, CHETAN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: BETTEGOWDA, CHETAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.