Analyzing CAR-T cell therapies using advanced imaging techniques
Official title: High-Throughput, Label-Free, Unsupervised Image Analysis of CAR-T Cell Data
Funded at Ursa Analytics, INC. · NIH-10918936 · Data updated 2026-11-12
This study is looking at ways to make CAR-T cell therapies, which are special treatments for cancer using your own immune cells, even better and safer by using new imaging techniques that don’t change how the cells behave.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ursa Analytics, INC. NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | May 15, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $285,577 |
| NIH project number | 1R43GM153054-01A1 |
| Project ID | NIH-10918936 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing CAR-T cell therapy for cancers such as lymphomas, leukemias, or multiple myelomas.
✕Less likely to help
Patients who are not receiving CAR-T cell therapies or those with cancers not currently treated by these therapies may not benefit from this research.
What this research studies
This research focuses on improving the analysis of CAR-T cell therapies, which are personalized treatments using modified T cells to target cancer. By employing high-throughput, label-free imaging techniques, the project aims to better understand how these therapies work and identify any potential side effects caused by small particle aggregates. The methodology involves analyzing cell cultures and their responses to treatment without the need for labeling, which can alter cell behavior. This approach could lead to more effective and safer CAR-T therapies for patients.
Why it matters
Potential benefit: If successful, this research could enhance the safety and effectiveness of CAR-T cell therapies, potentially leading to better outcomes for cancer patients.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques for analyzing biologic therapies, indicating that this approach could yield valuable insights.
Where this research is happening
-
Ursa Analytics, INC.
Denver, United States Active
Researchers
- Principal investigator: Calderon, Christopher Peter — Ursa Analytics, INC.
- Study coordinator: Calderon, Christopher Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.