Analyzing CAR-T cell therapies using advanced imaging techniques
High-Throughput, Label-Free, Unsupervised Image Analysis of CAR-T Cell Data
['FUNDING_SBIR_1'] · URSA ANALYTICS, INC. · NIH-10918936
This study is looking at ways to make CAR-T cell therapies, which are special treatments for cancer using your own immune cells, even better and safer by using new imaging techniques that don’t change how the cells behave.
Quick facts
| Phase | ['FUNDING_SBIR_1'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | URSA ANALYTICS, INC. (nih funded) |
| Locations | 1 site (DENVER, UNITED STATES) |
| Trial ID | NIH-10918936 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the analysis of CAR-T cell therapies, which are personalized treatments using modified T cells to target cancer. By employing high-throughput, label-free imaging techniques, the project aims to better understand how these therapies work and identify any potential side effects caused by small particle aggregates. The methodology involves analyzing cell cultures and their responses to treatment without the need for labeling, which can alter cell behavior. This approach could lead to more effective and safer CAR-T therapies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing CAR-T cell therapy for cancers such as lymphomas, leukemias, or multiple myelomas.
Not a fit: Patients who are not receiving CAR-T cell therapies or those with cancers not currently treated by these therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the safety and effectiveness of CAR-T cell therapies, potentially leading to better outcomes for cancer patients.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques for analyzing biologic therapies, indicating that this approach could yield valuable insights.
Where this research is happening
DENVER, UNITED STATES
- URSA ANALYTICS, INC. — DENVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CALDERON, CHRISTOPHER PETER — URSA ANALYTICS, INC.
- Study coordinator: CALDERON, CHRISTOPHER PETER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers