Analyzing brain connectivity using fluorescence techniques
Fluorescence-based methods for microconnectivity analysis in neocortex
['FUNDING_OTHER'] · CARNEGIE-MELLON UNIVERSITY · NIH-10413555
This study is looking at new ways to see how brain cells connect with each other, which could help us understand how learning and experiences change those connections, especially as we age or deal with certain diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CARNEGIE-MELLON UNIVERSITY (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10413555 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced fluorescence-based methods to analyze the connectivity of neural cells in the brain. By utilizing state-of-the-art Expansion Microscopy techniques, the study aims to improve the accuracy and resolution of synaptic measurements in brain tissue. The research will also explore how these methods can provide insights into changes in neural connectivity related to learning and experience. Patients may benefit from a better understanding of how brain connectivity is affected by age and disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological disorders or those experiencing cognitive changes related to age.
Not a fit: Patients with stable neurological conditions and no cognitive changes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for neurological conditions by enhancing our understanding of brain connectivity.
How similar studies have performed: Other research has shown success with fluorescence-based methods in neuronal cultures, but this specific application in brain connectivity analysis is relatively novel.
Where this research is happening
PITTSBURGH, UNITED STATES
- CARNEGIE-MELLON UNIVERSITY — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARTH, ALISON L — CARNEGIE-MELLON UNIVERSITY
- Study coordinator: BARTH, ALISON L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.