Analyzing brain circuits in healthy and diseased states
Official title: Architectonic analysis of complex cortical circuits in healthy and diseased brain
Funded at University of Virginia · NIH-10749697 · Data updated 2026-11-12
This study is looking at how brain circuits work in both healthy people and those with Alzheimer's disease, using special techniques to better understand what happens in the brain when things go wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,041,557 |
| NIH project number | 1RF1NS131762-01A1 |
| Project ID | NIH-10749697 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's or those without cognitive impairments may not benefit from this research.
What this research studies
This research investigates the complex circuits in the brain, particularly focusing on how these circuits function in both healthy and diseased conditions, such as Alzheimer's disease. Using advanced techniques like simultaneous patch-clamp recordings, the researchers aim to reconstruct and analyze the architecture of specific neuronal circuits. This approach allows for a detailed understanding of how these circuits operate and how they may be altered in disease states, providing insights into brain physiology and pathology.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in using advanced recording techniques to analyze brain circuits, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Beenhakker, Mark — University of Virginia
- Study coordinator: Beenhakker, Mark
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.