Analyzing brain cell types to understand Alzheimer's disease better
Official title: Statistical methods for population-level cell-type-specific analyses of tissue omics data for Alzheimer's disease
Funded at University of Pittsburgh at Pittsburgh · NIH-10990548 · Data updated 2026-11-12
This study is looking at brain samples from people with Alzheimer's to learn more about the disease and find ways to improve prevention and treatment, so it could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $340,493 |
| NIH project number | 5R01AG080590-03 |
| Project ID | NIH-10990548 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not receive benefit from this research.
What this research studies
This research focuses on improving our understanding of Alzheimer's disease by analyzing complex biological data from brain tissues. It aims to enhance the estimation of different cell types in brain samples and identify specific regions of DNA methylation that are linked to Alzheimer's. By utilizing advanced techniques like single-cell RNA sequencing, the study seeks to uncover the cellular mechanisms that contribute to the disease. Patients may benefit from insights that could lead to better prevention and treatment strategies for Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention and treatment options for Alzheimer's disease.
How similar studies have gone: Previous research using similar cellular analysis techniques has shown promise in understanding other neurodegenerative diseases, indicating potential for success in this area as well.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Wang, Jiebiao — University of Pittsburgh at Pittsburgh
- Study coordinator: Wang, Jiebiao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.