Analyzing biomarkers to predict Alzheimer's disease onset and quality of life.
Official title: Integrative analysis for patient-centered outcomes and time-to-event data in Alzheimer's disease
Funded at Yale University · NIH-10634872 · Data updated 2026-11-12
This study is looking for ways to spot early signs of Alzheimer's disease by analyzing genetic information and health records, so we can better understand who might be at risk and how to help them live well before any symptoms show up.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,330,283 |
| NIH project number | 1RF1AG081413-01 |
| Project ID | NIH-10634872 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk for Alzheimer's disease, particularly those in the asymptomatic stage.
✕Less likely to help
Patients who are already diagnosed with advanced Alzheimer's disease may not benefit from this research.
What this research studies
This research aims to develop advanced analytical methods to identify individual biomarker patterns that are linked to the onset of Alzheimer's disease, even before symptoms appear. By examining genetic factors and utilizing extensive electronic health records, the project seeks to create dynamic predictions of disease risk while considering the impact on patients' quality of life. The approach focuses on overcoming current limitations in understanding how biomarkers change over time and their relationship with disease progression. This could lead to more personalized management strategies for individuals at risk of Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of Alzheimer's disease, improving patients' quality of life.
How similar studies have gone: Previous research has shown promise in using biomarker analysis for Alzheimer's, but this project aims to introduce novel methodologies that have not been extensively tested.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Zhao, Yize — Yale University
- Study coordinator: Zhao, Yize
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.