Analyzing and improving understanding of early colonic lesions
Translational Pathology and Data Analysis Core (TPDAC)
This study is looking to better understand early signs of colon issues, like adenomas, by collecting and analyzing samples from patients to help improve how we study these conditions, using cutting-edge technology to get a clearer picture of what's happening at a cellular level.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10926957 on NIH RePORTER |
What this research studies
This research focuses on providing essential biospecimens and data analysis services to support projects aimed at understanding early colonic lesions, such as colonic adenomas. By utilizing advanced technologies and expertise from multiple departments at the University of Wisconsin and the Fred Hutchinson Cancer Research Center, the project aims to enhance the analysis of these lesions at a molecular level. Patients' biospecimens will be collected and analyzed to ensure diverse representation and improve the accuracy of findings. The research employs innovative methods like Digital Spatial Profiling and Single Cell Sequencing to gain insights into the biology of these conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals with a history of colonic adenomas or those undergoing screening for colorectal conditions.
Not a fit: Patients without any history of colonic lesions or those not undergoing relevant screenings may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment strategies for early colonic lesions, potentially reducing the risk of colorectal cancer.
How similar studies have performed: Previous research utilizing similar advanced analytical techniques has shown promise in enhancing our understanding of cancer biology, indicating a potential for success in this approach.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Matkowskyj, Kristina a. — Fred Hutchinson Cancer Center
- Study coordinator: Matkowskyj, Kristina a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.