Analyzing 3D images of mouse models to understand structural birth defects
Project II - 3D Quantitative Analysis of Mouse Models of Structural Birth Defects Through Computational Anatomy
This study is looking at how advanced 3D imaging can help us understand birth defects by examining mice with similar issues, so we can learn more about how genetic changes might affect human development.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11003303 on NIH RePORTER |
What this research studies
This research investigates the use of advanced 3D imaging techniques to analyze mouse models that exhibit structural birth defects. By utilizing high-resolution microCT scans and deep-learning models, the project aims to create a detailed anatomical template of normal and mutant fetal mice. This approach will allow researchers to assess variations in mouse development and improve the accuracy of morphological characterizations. Ultimately, the goal is to enhance our understanding of how genetic mutations can lead to birth defects in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of structural birth defects or genetic mutations that may lead to such conditions.
Not a fit: Patients without a genetic predisposition to structural birth defects or those not affected by such conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for structural birth defects in humans.
How similar studies have performed: Other research has shown success in using advanced imaging and computational techniques to analyze anatomical structures, indicating a promising approach in this area.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Maga, Ali Murat — Seattle Children's Hospital
- Study coordinator: Maga, Ali Murat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.