An OvaryChip to find harmful chemicals for ovaries
An ovary-on-a-chip to identify ovarian toxicity
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11369456
This project uses a special "OvaryChip" to discover which chemicals might harm a woman's ovaries and lead to infertility or hormonal problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11369456 on ClinicalTrials.gov |
What this research studies
Many everyday chemicals and medicines can harm a woman's ovaries, potentially causing early ovarian failure, hormone imbalances, and difficulty getting pregnant. Currently, it's hard to test all these chemicals for their effects on the ovaries. Our team has created a miniature "OvaryChip" that acts like a real human ovary, showing how follicles grow, hormones are made, and eggs mature. We are now working to make this chip faster and more efficient to test many chemicals quickly. This will help us understand how environmental toxins affect ovarian health.
Who could benefit from this research
Good fit: This research is foundational and does not directly involve patient participation, but it aims to benefit women concerned about ovarian health, infertility, and hormonal imbalances caused by environmental factors.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not receive benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could help identify harmful chemicals that affect ovarian health, potentially leading to better protection for women's fertility and hormonal balance.
How similar studies have performed: The researchers have previously developed an OvaryChip that successfully mimics human ovarian function, providing a strong foundation for this accelerated testing approach.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIAO, SHUO — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: XIAO, SHUO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.