An intravaginal ring that prevents HIV and acts as a nonhormonal contraceptive.
Official title: Next Generation Multipurpose Prevention Technology: An Intravaginal Ring for HIV Prevention and Nonhormonal Contraception
Funded at Oak Crest Institute of Science · NIH-10805424 · Data updated 2026-11-12
This study is testing a new type of intravaginal ring that helps prevent both HIV and unwanted pregnancies, making it easier for women, especially in sub-Saharan Africa, to take care of their health with just one product.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oak Crest Institute of Science NIH-funded |
| Lab location | 1 site (Monrovia, United States) |
| Project start | May 5, 2020 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $728,629 |
| NIH project number | 5R01HD101344-05 |
| Project ID | NIH-10805424 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are young women in sub-Saharan Africa who are at risk of HIV infection and are seeking nonhormonal contraceptive options.
✕Less likely to help
Patients who are not at risk of HIV or who prefer hormonal contraceptive methods may not benefit from this research.
What this research studies
This research focuses on developing a next-generation intravaginal ring that serves dual purposes: preventing HIV infection and providing nonhormonal contraception. The approach involves creating a novel contraceptive agent using multivalent monoclonal antibodies that block sperm from reaching the egg, combined with antiretroviral agents that are effective in preventing HIV. This innovative device aims to increase uptake among women, particularly in sub-Saharan Africa, by addressing both their contraceptive needs and HIV prevention in a single product.
Why it matters
Potential benefit: If successful, this research could provide women with a safe and effective method for preventing both HIV and unintended pregnancies.
How similar studies have gone: While the concept of multipurpose prevention technologies is gaining interest, this specific approach using a dual-action intravaginal ring is relatively novel and has not been extensively tested in prior research.
Where this research is happening
-
Oak Crest Institute of Science
Monrovia, United States Active
Researchers
- Principal investigator: Baum, Marc Michael — Oak Crest Institute of Science
- Study coordinator: Baum, Marc Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.