Alzheimer’s risk in older Latino adults
Official title: A Population-Based Risk Study of Alzheimer’s Disease
Funded at Rush University Medical Center · NIH-11398004 · Data updated 2026-11-12
This project will learn what raises the risk of Alzheimer’s and mild cognitive problems in older Latino adults by building a local cohort, collecting clinical and genetic information, and looking at heart health and inflammation factors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,055,665 |
| NIH project number | 4UH3AG083289-03 |
| Project ID | NIH-11398004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are older Latino adults living in Chicago's East Side area, with or without memory symptoms, who are willing to attend in-person assessments.
✕Less likely to help
People who are not Latino, live far from Chicago, or are unwilling or unable to attend in-person visits are unlikely to benefit directly from participating.
What this research studies
You would be invited to join a new community-based Latino cohort run out of Rush University in Chicago's East Side. The team will build community outreach and an external advisory board, enroll about 300 participants, and maintain ongoing engagement and resource sharing with the community. Participants will receive neurological assessments and provide information and samples for genetic testing (including APOE ε4), cardiovascular risk measures, and inflammation markers. Researchers will compare dementia and mild cognitive impairment rates and genetic links in Latino participants to patterns seen in non-Hispanic White groups.
Why it matters
Potential benefit: If successful, this work could improve early detection, prevention strategies, and culturally tailored care for Alzheimer’s in Latino communities.
How similar studies have gone: Other population studies have linked APOE ε4 and cardiovascular risk to dementia in non-Hispanic White groups, but Latino-specific, population-based evidence is limited.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Rajan, Kumar B. — Rush University Medical Center
- Study coordinator: Rajan, Kumar B.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.