Alzheimer's Neuroimaging and Biomarker Initiative
Official title: Alzheimer's Disease Neuroimaging Initiative (ADNI4)
Funded at Northern California Institute/res/edu · NIH-11386817 · Data updated 2026-11-12
Collecting brain scans, blood, spinal fluid, and memory tests from people with and without memory problems to find markers that help detect and track Alzheimer's and improve trials.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2004 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $18,719 |
| NIH project number | 3U19AG024904-18S3 |
| Project ID | NIH-11386817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults across the memory spectrum — people with normal cognition, subjective memory concerns, mild cognitive impairment, or Alzheimer's dementia — who are willing to undergo scans and give blood or CSF samples.
✕Less likely to help
Participants should not expect direct treatment or symptom improvement from taking part, especially if they are seeking immediate therapeutic benefit or cannot tolerate imaging or lumbar puncture procedures.
What this research studies
If you join, researchers will collect MRI and PET brain scans, cognitive tests, blood samples, sometimes spinal (CSF) fluid, and genetic data and will follow you over time. Your de-identified data and samples are shared widely with other researchers to speed discoveries. ADNI4 focuses on using blood-based biomarkers and increasing enrollment of people from underrepresented communities so results apply to more people. Many participants are continuing from earlier ADNI phases and visits include both in-person testing and some remote follow-up.
Why it matters
Potential benefit: Could lead to earlier and more accurate detection of Alzheimer's and better-designed treatments for people in the future.
How similar studies have gone: Yes — prior ADNI phases produced thousands of publications, shaped clinical trial designs (including work used for aducanumab trials), and helped validate biomarkers used widely in Alzheimer's research.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Weiner, Michael W — Northern California Institute/res/edu
- Study coordinator: Weiner, Michael W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.