Alzheimer's imaging and biomarker initiative (ADNI4)
Official title: Alzheimer's Disease Neuroimaging Initiative (ADNI4)
Funded at Northern California Institute/res/edu · NIH-10906268 · Data updated 2026-11-12
This project collects brain scans, blood and spinal fluid samples and health information from people with and without memory problems to improve tests that spot Alzheimer's earlier and more accurately.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2004 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $28,923,281 |
| NIH project number | 5U19AG024904-18 |
| Project ID | NIH-10906268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults across the memory spectrum — people with normal cognition, mild cognitive impairment, or early Alzheimer dementia — with a priority for enrollment of underrepresented racial and ethnic groups.
✕Less likely to help
People seeking an immediate treatment benefit should not expect direct clinical improvement because ADNI4 is an observational biomarker and data-sharing effort rather than a treatment trial.
What this research studies
If you join ADNI4 you would provide medical history, cognitive testing, brain imaging, and blood and sometimes spinal fluid samples, and some participants are followed over time. The project combines these data to refine blood, imaging, and other biomarkers that can predict who will develop dementia. ADNI4 places special emphasis on adding more participants from underrepresented racial and ethnic groups so the results apply to more people. The program maintains and widely shares its data and samples so other researchers and clinical trials can build on the findings.
Why it matters
Potential benefit: If successful, this work could enable earlier and more reliable detection of Alzheimer's and help design better clinical trials and treatments for patients.
How similar studies have gone: Previous ADNI phases have produced thousands of publications and guided clinical trial design, including work used in aducanumab trials, so the approach is well-established and influential.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Weiner, Michael W — Northern California Institute/res/edu
- Study coordinator: Weiner, Michael W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.