Alzheimer's genetics in African and Hispanic ancestry communities
Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)
This project will collect DNA and health information from thousands of people of African and Hispanic ancestry to better understand genetic risks for Alzheimer’s disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11380141 on NIH RePORTER |
What this research studies
If I join, researchers will use community-sensitive outreach to recruit people of African, African American, African Caribbean, and Hispanic/Latino backgrounds and collect health information and DNA samples. The effort plans to enroll and genotype about 13,000 participants to build a large genomic resource focused on underrepresented populations. Samples and data will be analyzed to find genetic differences that affect Alzheimer’s risk in these ancestry groups. The team aims to overcome historical mistrust by working with communities and tailoring recruitment and retention approaches.
Who could benefit from this research
Good fit: Adults of African, African American, African Caribbean, or Hispanic/Latino ancestry, with or without Alzheimer’s disease or related dementias, who are willing to provide health information and a DNA sample are ideal candidates.
Not a fit: People who are not from the targeted ancestry groups or those seeking immediate clinical treatment are unlikely to receive direct personal benefit from participation.
Why it matters
Potential benefit: Results could lead to more accurate genetic risk information and better-targeted prevention or treatments for people of African and Hispanic ancestry.
How similar studies have performed: Earlier, smaller genetic studies in African American groups found different risk signals (for example APOE effect differences and ABCA7) but were underpowered, so this larger effort builds on those findings.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Pericak-Vance, Margaret a. — University of Miami School of Medicine
- Study coordinator: Pericak-Vance, Margaret a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.