Alcohol and risk of new TB infection and TB disease in people living with HIV
The Role of Alcohol Use in Incident TB Infection and Active TB Disease Among Persons Living with HIV
This project compares whether adults with HIV who drink heavily are more likely to get a new TB infection or develop active TB disease after preventive therapy, especially in Uganda.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11146592 on NIH RePORTER |
What this research studies
You would be part of a group of adults living with HIV who previously tested negative for TB and received TB preventive therapy. Researchers will record how much alcohol participants drink and will repeat TB infection tests and clinical checks over time. The team will compare how often people who drink heavily versus lightly or not at all get newly infected with TB or develop active TB disease. Findings will be used to suggest prevention steps like helping people reduce drinking or offering repeat short-course preventive TB treatment.
Who could benefit from this research
Good fit: Ideal candidates are adults living with HIV—particularly those who drink alcohol and who live in high HIV/TB areas such as Uganda—who previously tested negative for TB infection and received TB preventive therapy.
Not a fit: People without HIV, children, those who already have active TB, or people not in high-TB-burden settings are unlikely to benefit directly from participating.
Why it matters
Potential benefit: If successful, the work could help reduce TB infections and disease among people living with HIV who drink by guiding targeted prevention like alcohol-reduction support or repeat preventive therapy.
How similar studies have performed: Previous research shows heavy drinking is linked to higher TB rates and worse TB outcomes, but few studies have separately tracked new TB infection versus progression to disease, so this approach adds new information.
Where this research is happening
Boston, United States
- Boston Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Hahn, Judith Alissa — Boston Medical Center
- Study coordinator: Hahn, Judith Alissa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.