AIE, BBB Regulation, and Neurovascular Health in Alzheimer’s-Related Dementia
Official title: AIE, Blood-Brain Barrier Regulation, and Neurovascular Integrity in Amyloidopathy
Funded at State University of Ny,binghamton · NIH-11416537 · Data updated 2026-11-12
This NIH grant supports work on how intermittent alcohol exposure in adolescence affects the brain’s protective barrier and blood flow in people and animal models at risk for Alzheimer’s-related dementia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project start | September 1, 2009 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $260,964 |
| NIH project number | 5P50AA017823-18 |
| Project ID | NIH-11416537 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adolescents and adults with a history of alcohol exposure or risk factors for Alzheimer’s-related dementia, including individuals with AD or ADRD pathology.
✕Less likely to help
Individuals without a history of alcohol exposure or those without risk factors for neurovascular dysfunction may have limited direct benefit.
What this research studies
The research examines how the blood-brain barrier changes after alcohol exposure during adolescence and how these changes relate to Alzheimer’s disease pathways. It builds on prior findings showing sex- and brain-region-specific effects on barrier integrity and increases in amyloid-related processes. The project uses animal models to study mechanisms and may explore human brain tissue findings to connect lab results with human biology. Goals include understanding neurovascular risk factors that could contribute to cognitive decline and dementia later in life.
Why it matters
Potential benefit: Better understanding of how adolescent alcohol exposure might influence brain barriers and dementia risk, potentially guiding prevention or targeted therapies.
How similar studies have gone: Previous work shows sex- and region-specific neurovascular changes after adolescent alcohol exposure and links to amyloid/tau pathology, supporting further investigation.
Where this research is happening
-
State University of Ny,binghamton
Binghamton, United States Active
Researchers
- Principal investigator: Deak, Terrence — State University of Ny,binghamton
- Study coordinator: Deak, Terrence
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.