AI-powered high-resolution eye scans to measure and classify inflammation in uveitis
Quantification and Classification of Aqueous and Vitreous Inflammation in Uveitis Using Deep Learning Analysis of Ultrahigh-Resolution OCT
['FUNDING_R21'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11163446
This project will use ultrahigh-resolution OCT scans plus deep learning to count and identify inflammatory cells in the eyes of people with uveitis.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11163446 on ClinicalTrials.gov |
What this research studies
If you have uveitis, researchers will take very detailed, noninvasive OCT images of the fluid in the front (aqueous) and back (vitreous) of your eye. They will use artificial intelligence to count inflammatory cells seen in those images and try to classify different cell types. The team will also estimate protein levels by measuring how light scatters in the images. Together these image-based measurements aim to help doctors distinguish types of uveitis and follow disease severity and treatment response over time.
Who could benefit from this research
Good fit: People diagnosed with uveitis who can undergo OCT imaging and have active or suspected intraocular inflammation would be the ideal candidates.
Not a fit: People without uveitis or those who cannot receive clear OCT images (for example due to dense corneal or lens opacities) are unlikely to benefit from this project.
Why it matters
Potential benefit: Could provide a faster, noninvasive way to help diagnose types of uveitis and track how well treatments are working.
How similar studies have performed: OCT and AI have been used separately in eye disease, but combining ultrahigh-resolution OCT with deep learning to count and classify inflammatory cells in the aqueous and vitreous is a relatively new approach with limited prior clinical validation.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, YAN — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: LI, YAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.