AI-built genetic map to understand Alzheimer's disease
AIM-AI: an Actionable, Integrated and Multiscale genetic map of Alzheimer's disease via deep learning
Using artificial intelligence to combine genetic, molecular, and brain imaging data to find genetic clues that could help people with or at risk for Alzheimer's disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11180316 on NIH RePORTER |
What this research studies
This project will use AI to analyze large collections of genetic information, brain scans, and other molecular data from people with Alzheimer's or at risk. Researchers will link gene changes to specific brain cell types and regions using single-cell and other 'omics' data alongside neuroimaging. The team aims to turn complex genetic signals into a clear, multiscale map that points to biological processes and possible drug targets. If you contribute data or samples, your information could help guide future tests and therapies.
Who could benefit from this research
Good fit: People with Alzheimer's disease, mild cognitive impairment, or individuals at genetic risk who can provide genetic samples, brain imaging, or other research data are ideal candidates.
Not a fit: Those seeking an immediate new therapy or people whose cognitive problems are due to non-Alzheimer causes may not receive direct clinical benefit from this work.
Why it matters
Potential benefit: Could reveal clearer genetic targets for new treatments or better tests to predict or understand Alzheimer's disease.
How similar studies have performed: Prior AI and genetic studies have found promising signals in Alzheimer's, but a fully integrated, multiscale AI genetic map of the kind proposed remains relatively new.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Zhao, Zhongming — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Zhao, Zhongming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.