NIH-funded research U01 cooperative agreement

AI-assisted radiotherapy planning for cervical and head and neck cancer

Official title: ARCHERY: Artificial Intelligence based Radiotherapy treatment planning for Cervical and Head and Neck cancer

Funded at University College London · NIH-11399432 · Data updated 2026-11-12

This project uses artificial intelligence to make radiotherapy planning faster and more accurate for people with cervical or head and neck cancer, especially in low- and middle-income countries.

More Head and Neck Cancer research and trials

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionUniversity College London
NIH-funded
Lab location1 site (London, United Kingdom)
Project startSeptember 1, 2022
Project endAugust 31, 2027
Funding year2025
Award (this year)$25,800
NIH project number3U01CA269143-03S5
Project IDNIH-11399432 on NIH RePORTER

Who could benefit from this research

Could help

People diagnosed with cervical or head and neck cancer who are planned to receive radiotherapy at a participating center, particularly in low- and middle-income countries, are ideal candidates.

Less likely to help

Patients who are not receiving radiotherapy, those with cancers outside the targeted sites, or those needing highly individualized or experimental radiation approaches may not benefit from this project.

What this research studies

You would have your CT scans processed by AI that automatically outlines tumors and nearby organs at risk and suggests radiation beam positions and shapes, with clinicians reviewing the results. The team plans a non-randomized prospective study enrolling about 706 patients (roughly 353 with cervical cancer and 353 with head and neck cancer) to compare AI-generated plans to current practice. Researchers will measure plan quality, time saved, and economic impact with the goal of reducing planning time from weeks to less than a day and lowering workforce needs. The work is led by University College London in collaboration with partner treatment centers, focusing on sites where radiotherapy access is limited.

Why it matters

Potential benefit: If successful, this could shorten radiotherapy wait times, improve treatment accuracy, and expand access to curative radiotherapy in resource-limited settings.

How similar studies have gone: Previous pilot studies of AI auto-contouring and automated planning have shown promising accuracy and time savings, but large prospective clinical evaluations in LMIC settings remain limited.

Where this research is happening

  • University College London
    London, United Kingdom
    Active

Researchers

  • Principal investigator: Aggarwal, Ajay — University College London
  • Study coordinator: Aggarwal, Ajay

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.