AI and image-based tools to improve early cancer detection
Quantitative Imaging Clinical Validation Center at Moffitt Cancer Center
This program uses AI and detailed measurements from medical scans to find cancers earlier and cut down on false alarms for people getting cancer screening.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11182615 on NIH RePORTER |
What this research studies
Researchers will use medical images (such as mammograms and CT scans) together with AI and radiomics (detailed image measurements) to create and test image-based biomarkers that help tell cancerous from noncancerous findings. The team will expand a secure image repository and apply machine-learning models to predict which findings are likely malignant, indolent, or aggressive. They have previously validated markers for breast density and lung-nodule behavior and will validate and benchmark new models across partner sites to improve reliability. If you share your scans or take part at a participating site, your images could help refine tools that guide screening decisions and reduce unnecessary procedures.
Who could benefit from this research
Good fit: People undergoing breast or lung cancer screening, especially those with indeterminate or suspicious imaging findings like BI-RADS 4 breast lesions or pulmonary nodules, are the most relevant candidates.
Not a fit: People not undergoing imaging-based screening or whose cancers are not detectable by current imaging technologies are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could make cancer screening more accurate, reduce unnecessary follow-up tests and biopsies, and help identify cancers that need timely treatment.
How similar studies have performed: Similar radiomics and AI approaches have shown promising results and this center has already validated several image biomarkers, though broader clinical adoption is still developing.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Heine, John J — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Heine, John J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.