AF10-fusion leukemias in children and adults: how they grow and how to stop them
Molecular Pathogenesis of AF10-Rearranged Leukemias
This project looks into how AF10 gene fusions drive aggressive leukemias in children and adults to identify safer, more targeted treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11308651 on NIH RePORTER |
What this research studies
Researchers will analyze genetic and clinical data from children and adults whose leukemias carry AF10 gene fusions and study patient tumor samples. They will build lab models of AF10-fusion leukemias using cells and experimental systems to see what makes the cancer cells keep growing and resist therapy. The team will search for molecular weaknesses caused by the fusion proteins and test drugs in the lab that might selectively kill those leukemia cells. Results aim to point toward new, less toxic therapies and better ways to identify high-risk patients.
Who could benefit from this research
Good fit: Ideal candidates are children and adults with AML or T-ALL whose leukemia tests positive for AF10 gene fusions, including newly diagnosed or relapsed patients.
Not a fit: Patients without AF10 fusions or with unrelated cancer types are unlikely to directly benefit from this research.
Why it matters
Potential benefit: If successful, this work could lead to targeted, less toxic treatments and improved risk prediction for patients with AF10-rearranged leukemias.
How similar studies have performed: Targeted drugs have worked well for some other fusion-driven leukemias, but AF10 fusions are less studied and direct targeted therapies for them are largely novel and untested.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Deshpande, Aniruddha J. — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Deshpande, Aniruddha J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.