Advancing treatments for ALS and related motor neuron disorders
Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe)
This program connects clinics, researchers, and patient groups to speed up development of better treatments and trials for people with ALS and related conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11171883 on NIH RePORTER |
What this research studies
You would join a network of clinics and researchers working together to make it easier to find and test new ALS treatments. They collect medical histories, standardized outcome measures, genetic data, and blood or tissue samples and store them in a shared database to improve trial design and biomarker discovery. The consortium runs multi-center studies, registries, and trial-readiness activities so new therapies can be tested faster and more reliably across patients. Participation may involve clinic visits, questionnaires, and giving biological samples, with some follow-up done remotely depending on the site.
Who could benefit from this research
Good fit: People diagnosed with ALS or related motor neuron disorders (including ALS-FTD, PLS, PMA, hereditary spastic paraplegia, or multisystem proteinopathy) and individuals with known genetic risk factors such as C9ORF72 are typical candidates.
Not a fit: People without ALS or related neurologic conditions, or those unable to access a participating center, are unlikely to benefit directly from this consortium's activities.
Why it matters
Potential benefit: If successful, this work could speed up clinical trials, identify useful biomarkers, and bring new treatments to people with ALS and related disorders sooner.
How similar studies have performed: Other rare-disease networks and ALS consortia have improved patient registries and biomarker research, though converting those advances into effective treatments is still ongoing.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Benatar, Michael — University of Miami School of Medicine
- Study coordinator: Benatar, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.