Advancing continuous manufacturing of monoclonal antibodies with a validated modeling platform
Official title: Advancing continuous biomanufacturing of monoclonal antibodies using an experimentally validated modeling platform
Funded at University of Delaware · NIH-11420164 · Data updated 2026-11-12
A research team at the University of Delaware will develop and test a combined experimental and computer model approach to improve how monoclonal antibodies are produced continuously.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | September 1, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $884,858 |
| NIH project number | 5U01FD007695-05 |
| Project ID | NIH-11420164 on NIH RePORTER |
Who could benefit from this research
✓Could help
This grant does not recruit patients; it focuses on manufacturing technologies and modeling.
✕Less likely to help
Patients are not directly enrolled; the research center on processes rather than clinical care.
What this research studies
This project creates an experimental setup alongside a computational framework to study continuous manufacturing of monoclonal antibodies. It aims to build a multiscale model that links cell culture conditions with downstream purification to predict product quality and process performance. The work will validate the model with real experimental data, then use it to optimize operating conditions and enable better process control. The ultimate goal is to shorten development times and improve consistency in biologics manufacturing with fewer impurities.
Why it matters
Potential benefit: If successful, the approach could lead to more efficient, reliable, and scalable production of monoclonal antibodies for patients.
How similar studies have gone: Previous work in biomanufacturing modeling shows promise in linking process parameters to product quality, supporting this direction as plausible and potentially impactful.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Ierapetritou, Marianthi — University of Delaware
- Study coordinator: Ierapetritou, Marianthi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.