Advanced technology for studying protein structures and dynamics
Official title: High Q Technologies FATHOM Pulse EPR Spectrometer
Funded at Saint Louis University · NIH-10851220 · Data updated 2026-11-12
This study is all about getting a new, advanced tool to help scientists understand how proteins change shape and work together, which is important for many health-related research projects, and it will also provide great learning opportunities for students and researchers in Missouri and nearby areas.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,600,000 |
| NIH project number | 1S10OD036230-01 |
| Project ID | NIH-10851220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions related to protein dysfunction or diseases influenced by protein dynamics.
✕Less likely to help
Patients with conditions unrelated to protein structure or dynamics may not receive direct benefits from this research.
What this research studies
This research focuses on acquiring a state-of-the-art Pulse EPR Spectrometer to investigate the structural dynamics of proteins and their complexes. By utilizing advanced techniques like DEER spectroscopy, the research aims to measure conformational changes in biomacromolecules under physiological conditions. This technology will enhance the sensitivity and capabilities of existing instruments, allowing for more comprehensive studies and training opportunities for students and researchers in the field. The facility will serve as a regional resource for researchers in Missouri and nearby states.
Why it matters
Potential benefit: If successful, this research could lead to a deeper understanding of protein functions and mechanisms, potentially impacting various medical and therapeutic applications.
How similar studies have gone: Previous research utilizing similar advanced spectroscopic techniques has shown promising results in understanding protein dynamics and functions.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Dastvan, Reza — Saint Louis University
- Study coordinator: Dastvan, Reza
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.