Advanced sequencing to map immune cells in lung infections
Sequencing Core
['FUNDING_OTHER'] · LA JOLLA INSTITUTE FOR IMMUNOLOGY · NIH-11095827
This program provides high-quality sequencing of immune cells from people with lung infections or vaccines to map how immune memory is formed.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LA JOLLA INSTITUTE FOR IMMUNOLOGY (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11095827 on ClinicalTrials.gov |
What this research studies
If you have had COVID-19, tuberculosis, or other lung infections or received related vaccines, researchers can use small blood or tissue samples to study your T cells. The core sorts cells, extracts RNA and DNA, and runs bulk and single-cell RNA sequencing, T cell receptor sequencing, and single-cell ATAC-seq to read gene activity and chromatin accessibility. All sample handling, library preparation, and high-throughput sequencing are done using standardized, quality-controlled pipelines so results are reproducible. The Sequencing Core then delivers processed data to project teams studying immune memory after infection or vaccination.
Who could benefit from this research
Good fit: Ideal candidates are people who have been infected with or vaccinated against SARS-CoV-2, Mycobacterium tuberculosis, or other lung pathogens and can provide blood or tissue samples.
Not a fit: People without a history of relevant lung infection or vaccination, or those unable or unwilling to provide biological samples, would not directly benefit from participating.
Why it matters
Potential benefit: This work could improve understanding of immune memory in lung infections and help guide better vaccines or therapies in the future.
How similar studies have performed: Similar sequencing and single-cell approaches have been widely used and successfully mapped immune cells in many prior studies.
Where this research is happening
LA JOLLA, UNITED STATES
- LA JOLLA INSTITUTE FOR IMMUNOLOGY — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEUMOIS, GREGORY — LA JOLLA INSTITUTE FOR IMMUNOLOGY
- Study coordinator: SEUMOIS, GREGORY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.