Advanced sequencing technologies for studying immune and genetic factors in health and disease
Core C: Genomics and Bioinformatics
This study is looking at how our genes and their activity affect our immune system, using advanced technology to help us understand health and disease better, and it’s for anyone interested in how these factors might lead to new treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11146717 on NIH RePORTER |
What this research studies
This research focuses on utilizing cutting-edge sequencing technologies to analyze genetic and epigenetic factors that influence immune responses. It employs a variety of next-generation sequencing methods, including whole exome sequencing and ATAC-seq, to investigate how these factors affect health and disease at both the bulk and single-cell levels. The project aims to provide detailed bioinformatics analyses to interpret the complex data generated, which can lead to a better understanding of disease mechanisms and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with specific immune-related conditions or those undergoing treatment that may benefit from genomic and epigenomic analysis.
Not a fit: Patients without immune-related conditions or those not involved in the clinical projects supported by this core may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for various diseases by uncovering critical genetic and immune-related insights.
How similar studies have performed: Previous research utilizing similar sequencing technologies has shown promising results in understanding immune responses and disease mechanisms, indicating a strong potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Fertig, Elana — Johns Hopkins University
- Study coordinator: Fertig, Elana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.