Advanced MRI to Detect Scarring in Transplanted Kidneys
Characterization of Renal Allograft Fibrosis and Prediction of Outcome Using a Quantitative MRI Approach
This project uses a special MRI scan to find scarring in transplanted kidneys, helping doctors understand how well the new kidney is working.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11086669 on NIH RePORTER |
What this research studies
Kidney transplantation is a life-changing treatment, but sometimes transplanted kidneys develop scarring, called fibrosis, which can affect how long they last. Currently, doctors often need a biopsy to check for this scarring, which is an invasive procedure with potential risks. This project aims to develop a new, non-invasive MRI technique that can accurately detect and measure scarring in transplanted kidneys without a biopsy. By using advanced MRI, we hope to get a clearer picture of kidney health and predict how well the transplant will function over time. This could lead to earlier and more personalized care for transplant recipients.
Who could benefit from this research
Good fit: Patients who have received a kidney transplant and are experiencing or at risk of progressive kidney dysfunction may be ideal candidates.
Not a fit: Patients who have not undergone a kidney transplant or do not have chronic renal disease would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this approach could provide a safer, more comfortable way to monitor kidney transplant health and predict long-term outcomes, potentially leading to better treatment decisions.
How similar studies have performed: While biopsies are the current standard, preliminary data from this team suggests that advanced MRI can capture kidney transplant fibrosis, indicating a promising, yet still developing, approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Lewis, Sara C — Icahn School of Medicine at Mount Sinai
- Study coordinator: Lewis, Sara C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.