Advanced mass spectrometry for studying large biological molecules
High-Resolution Tandem Mass Spectrometer to Support Large Molecule Structural Characterization
This study is using a special machine to look closely at big molecules in the body to better understand how they work, especially in diseases like Alzheimer's and Parkinson's, which could help find new ways to treat these conditions for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11097756 on NIH RePORTER |
What this research studies
This research focuses on utilizing a cutting-edge hybrid high-resolution tandem mass spectrometer to analyze the structure of large biological and synthetic molecules. By employing advanced techniques such as electrospray ionization and various activation methods, the research aims to enhance our understanding of biomolecular interactions, including those related to neurodegenerative diseases like Alzheimer's and Parkinson's. The instrument will support multiple NIH-funded projects, enabling detailed studies of protein interactions, therapeutic compounds, and more, which could lead to significant advancements in treatment strategies. Patients may benefit from the insights gained into the molecular mechanisms of their conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with neurodegenerative diseases, such as Alzheimer's or Parkinson's, as well as those with related health issues.
Not a fit: Patients with conditions unrelated to the biomolecular interactions being studied may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with neurodegenerative diseases and other serious health conditions.
How similar studies have performed: Previous research utilizing advanced mass spectrometry techniques has shown promising results in understanding complex biomolecular structures and interactions, indicating a strong potential for success in this area.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Loo, Joseph a — University of California Los Angeles
- Study coordinator: Loo, Joseph a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.