Advanced imaging tools for clear cell kidney cancer
Core D: Translational Imaging Core
Researchers are using new MRI and PET imaging tools to show a key cancer protein (HIF2α) inside clear cell kidney tumors in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11145113 on NIH RePORTER |
What this research studies
You would get advanced MRI and PET scans using a new tracer that binds the HIF2α protein to visualize clear cell kidney tumors. The Core supports both preclinical tumorgraft imaging and clinical imaging in people now that the tracer [18F]PT2385 has an FDA IND. The team expanded multiparametric MRI to look at tumor aggressiveness, blood vessel growth, and tumor heterogeneity, and is developing PET radiotracers to reveal oncogenic drivers and tumor–microenvironment interactions. The Translational Imaging Core helps investigators run these scans and develop imaging tools patients could access through participating projects.
Who could benefit from this research
Good fit: People with clear cell renal cell carcinoma (ccRCC) who are eligible for imaging studies or related clinical trials would be the best candidates.
Not a fit: People without ccRCC or those who are not eligible for imaging trials or who cannot travel to the imaging center are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this work could let doctors see HIF2α activity inside kidney tumors to better guide treatment choices and monitor response.
How similar studies have performed: Multiparametric MRI has been used in kidney cancer before, and the HIF2α radiotracer [18F]PT2385 is a novel approach with an FDA IND but limited prior human experience.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Pedrosa, Ivan — Ut Southwestern Medical Center
- Study coordinator: Pedrosa, Ivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.